Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6573257 | 1.00 | ESR2 (0.47) | ESR2NR1H2ADORA1USP2SMN1; SMN2 | |
| SCHEMBL15459811 | 0.88 | ESR2 (0.47) | ESR2NR1H2ADORA1USP2SMN1; SMN2 | |
| SCHEMBL25275525 | 0.88 | ESR2 (0.47) | ESR2NR1H2ADORA1USP2SMN1; SMN2 | |
| SCHEMBL15248097 | 0.86 | USP2 (0.41) | ESR2NR1H2USP2SMN1; SMN2MAPK1 | |
| SCHEMBL15459812 | 0.85 | ESR2 (0.45) | ESR2NR1H2ADORA1USP2SMN1; SMN2 | |
| SCHEMBL785941 | 0.84 | ESR2 (0.44) | ESR2NR1H2ADORA1USP2SMN1; SMN2 | |
| SCHEMBL803643 | 0.84 | ESR2 (0.44) | ESR2NR1H2ADORA1USP2SMN1; SMN2 | |
| SCHEMBL785942 | 0.84 | ESR2 (0.44) | ESR2NR1H2ADORA1USP2SMN1; SMN2 | |
| SCHEMBL15898449 | 0.84 | ESR2 (0.44) | ESR2NR1H2ADORA1USP2SMN1; SMN2 | |
| SCHEMBL28162024 | 0.84 | ESR2 (0.44) | ESR2NR1H2ADORA1USP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100369896-C | Cyclic amine compound | SANKYO CO (JP) | 2008-02-20 | — | — | CN | disclosed |
| CN-1192019-C | Cyclic amine derivatives | SANKYO CO (JP) | 2005-03-09 | — | — | CN | disclosed |
| EP-0934928-B1 | CYCLIC AMINE DERIVATIVES | SANKYO CO (JP) | 2004-10-13 | — | — | EP | disclosed |
| US-6610708-B1 | Anticoagulants | SANKYO COMPANY, LIMITED (JP) | 2003-08-26 | — | — | US | disclosed |
| EP-1063230-B1 | CYCLIC AMINO COMPOUNDS | SANKYO CO (JP) | 2003-04-23 | — | — | EP | disclosed |
| CN-1298389-A | Cyclic amine compound | SANKYO CO (JP) | 2001-06-06 | — | — | CN | disclosed |
| EP-1063230-A1 | CYCLIC AMINO COMPOUNDS | Sankyo Company Limited (JP) | 2000-12-27 | — | — | EP | disclosed |
| US-6087379-A | AN ANTICOAGULANT FOR THE TREATMENT AND PREVENTION OF DISEASES AS EMBOLISM, THROMBOSIS OR ARTERIOSCLEROSIS | SANKYO COMPANY, LIMITED (JP) | 2000-07-11 | — | — | US | disclosed |
| CN-1235596-A | Cyclic amine derivatives | SANKYO CO (JP) | 1999-11-17 | — | — | CN | disclosed |
| EP-0934928-A1 | CYCLIC AMINE DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1999-08-11 | — | — | EP | disclosed |