Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.68 |
| ▸ | SMO | Q99835 | 1/20 | 0.64 |
| ▸ | GBA1 | P04062 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6782804 | 0.89 | MAPK14 (0.73) | MAPK14SMORAB9AMAPTHTT | |
| SCHEMBL6487809 | 0.88 | MAPK14 (0.69) | MAPK14SMORAB9AMAPTHTT | |
| SCHEMBL2972180 | 0.87 | MAPK14 (0.55) | MAPK14SMOGBA1 | |
| SCHEMBL6485580 | 0.87 | MAPK14 (0.75) | MAPK14SMORAB9AMAPTHTT | |
| SCHEMBL7809567 | 0.85 | MAPK14 (0.67) | MAPK14SMO | |
| SCHEMBL6487603 | 0.84 | MAPK14 (0.60) | MAPK14SMORAB9AMAPTHTT | |
| SCHEMBL6484389 | 0.84 | MAPK14 (0.70) | MAPK14SMORAB9AMAPTHTT | |
| SCHEMBL6478056 | 0.84 | MAPK14 (0.68) | MAPK14SMORAB9AMAPTHTT | |
| SCHEMBL27533108 | 0.83 | GBA1 (0.54) | MAPK14GBA1RAB9AMAPTHTT | |
| SCHEMBL6488842 | 0.83 | MAPK14 (0.71) | MAPK14SMORAB9AMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077931-B1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 2004-11-17 | — | — | EP | claimed |