Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.56 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL23045112 | 1.00 | KMT2A (0.61) | KMT2ALMNATSHRALOX12ACHE | |
| Glutarate SCHEMBL29254246 | 0.90 | HDAC3 (0.56) | KMT2ALMNATSHRALOX12ACHE | |
| Adipic Acid SCHEMBL27076125 | 0.90 | HDAC3 (0.57) | KMT2ALMNATSHRALOX12ACHE | |
| Adipic Acid SCHEMBL27076123 | 0.90 | HDAC3 (0.57) | KMT2ALMNATSHRALOX12ACHE | |
| Glutarate SCHEMBL29254244 | 0.90 | HDAC3 (0.56) | KMT2ALMNATSHRALOX12ACHE | |
| Succinic Acid SCHEMBL28691128 | 0.89 | KMT2A (0.52) | KMT2ALMNATSHRALOX12ACHE | |
| Toluene SCHEMBL585499 | 0.88 | HDAC3 (0.59) | KMT2ALMNATSHRALOX12ACHE | |
| P-Xylene SCHEMBL28395578 | 0.88 | KMT2A (0.61) | KMT2ALMNATSHRACHENR4A2 | |
| Toluene SCHEMBL27691200 | 0.88 | KMT2A (0.50) | KMT2ALMNATSHRALOX12ACHE | |
| Toluene SCHEMBL28174147 | 0.88 | KMT2A (0.50) | KMT2ALMNATSHRALOX12ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021038889-A1 | METHOD FOR PRODUCING HETEROCYCLIDENE ACETAMIDE DERIVATIVE | 持田製薬株式会社 | 2021-03-04 | — | — | WO | disclosed |
| CN-109422873-A | A kind of post-processing approach of VE succinic acid macrogol ester | 广东东阳光药业有限公司 | 2019-03-05 | — | — | CN | disclosed |
| EP-1019364-B1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | BIOVITRUM AB (SE) | 2004-06-09 | — | — | EP | disclosed |
| US-6410585-B1 | THERAPY FOR NON-INSULIN DEPEND DIABETES | BIOVITRUM AB (SE) | 2002-06-25 | — | — | US | disclosed |
| US-6353023-B1 | AROMATIC COMPOUNDS WITH AMIDE GROUPS | PHARMACIA & UPJOHN COMPANY | 2002-03-05 | — | — | US | disclosed |
| EP-1019364-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999011606-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | PHARMACIA & UPJOHN COMPANY (US) | 1999-03-11 | — | — | WO | disclosed |