SCHEMBL6575294

SCHEMBL6575294

COc1ccc(CCN(C)CCOc2ccc(N)cc2Br)cc1OC

nearest known ligand 0.62

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.62
CYP3A4 P08684 2/20 0.62
CYP2D6 P10635 2/20 0.62
BLM P54132 2/20 0.60
PMP22 Q01453 1/20 0.60
KCNH2 Q12809 1/20 0.57
AOC3 Q16853 1/20 0.52
CYP19A1 P11511 1/20 0.51
SMPD1 P17405 5/20 0.48
KDM4E B2RXH2 4/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
CYP2C9 P11712 1/20 0.47
ATM Q13315 1/20 0.47
ALDH1A1 P00352 2/20 0.46
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
ABCB1 P08183 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6571947 0.86 CYP1A2 (0.62) CYP1A2CYP3A4CYP2D6BLMPMP22
SCHEMBL6575217 0.84 CYP1A2 (0.67) CYP1A2CYP3A4CYP2D6BLMPMP22
Hydrochloric Acid SCHEMBL9054039 0.83 BLM (0.68) CYP1A2CYP3A4CYP2D6BLMPMP22
SCHEMBL2770457 0.82 CYP1A2 (0.81) CYP1A2CYP3A4CYP2D6BLMPMP22
SCHEMBL6573041 0.81 CYP1A2 (0.55) CYP1A2CYP3A4CYP2D6BLMPMP22
SCHEMBL6573552 0.81 CYP1A2 (0.55) CYP1A2CYP3A4CYP2D6BLMPMP22
SCHEMBL6575856 0.79 KCNH2 (0.56) CYP1A2CYP3A4CYP2D6BLMPMP22
SCHEMBL7430428 0.79 CYP1A2 (1.00) CYP1A2CYP3A4CYP2D6BLMPMP22
Hydrochloric Acid SCHEMBL6575922 0.79 KCNH2 (0.77) CYP1A2CYP3A4CYP2D6BLMPMP22
SCHEMBL8789951 0.78 CYP3A4 (0.65) CYP1A2CYP3A4CYP2D6BLMPMP22

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0775689-B9 NOVEL AMINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF AS ANTIARRHYTHMIC C & C RES LABS (KR) 2004-09-15 EP disclosed
EP-0775689-B1 NOVEL AMINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF AS ANTIARRHYTHMIC C & C RES LABS (KR) 2003-09-03 EP disclosed
US-6057358-A POTASSIUM CHANNEL BLOCKING ANTIARRHYTHMIC DRUGS WITH LESS SIDE EFFECTS C&C RESEARCH LABS. (KR) 2000-05-02 US disclosed
EP-0775689-A1 NOVEL AMINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF AS ANTIARRHYTHMIC C & C RESEARCH LABS. (KR) 1997-05-28 EP disclosed