Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 11/20 | 0.42 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 4/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6573321 | 0.90 | GRIA4 (0.42) | GRIA4GRIA2PSEN1PSEN2APH1B | |
| SCHEMBL6762192 | 0.90 | GRIA4 (0.40) | GRIA4GRIA2PSEN1PSEN2APH1B | |
| SCHEMBL6573845 | 0.90 | GRIA4 (0.41) | GRIA4GRIA2PSEN1PSEN2APH1B | |
| SCHEMBL6573336 | 0.86 | GRIA4 (0.41) | GRIA4GRIA2PSEN1PSEN2APH1B | |
| SCHEMBL6573066 | 0.80 | GRIA4 (0.62) | GRIA4GRIA2PSEN1PSEN2APH1B | |
| SCHEMBL6574456 | 0.77 | GRIA4 (0.47) | GRIA4GRIA2PSEN1PSEN2APH1B | |
| SCHEMBL6573312 | 0.76 | GRIA4 (0.61) | GRIA4GRIA2CNR2KCNH2 | |
| SCHEMBL6573317 | 0.76 | GRIA4 (0.61) | GRIA4GRIA2CNR2KCNH2 | |
| SCHEMBL6762188 | 0.76 | GRIA4 (0.58) | GRIA4GRIA2KDM1AKCNH2 | |
| SCHEMBL6762187 | 0.76 | GRIA4 (0.58) | GRIA4GRIA2KDM1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1409452-A1 | SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2004-04-21 | — | — | EP | disclosed |
| WO-2002098846-A1 | SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-12-12 | — | — | WO | disclosed |