Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 13/20 | 0.69 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.53 |
| ▸ | CDK2 | P24941 | 6/20 | 0.53 |
| ▸ | PRKCA | P17252 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6576012 | 1.00 | CDK1 (0.69) | CDK1SRCPDGFRACCNE1CDK2 | |
| SCHEMBL6576100 | 0.92 | CDK1 (0.69) | CDK1PDGFRACCNE1CDK2PRKCA | |
| SCHEMBL6576095 | 0.92 | CDK1 (0.69) | CDK1PDGFRACCNE1CDK2PRKCA | |
| SCHEMBL6578906 | 0.90 | CDK1 (0.75) | CDK1SRCPDGFRACCNE1CDK2 | |
| SCHEMBL6576036 | 0.90 | CDK1 (0.75) | CDK1SRCPDGFRACCNE1CDK2 | |
| SCHEMBL6578314 | 0.85 | CDK1 (0.69) | CDK1SRCPDGFRACCNE1CDK2 | |
| SCHEMBL6578317 | 0.85 | CDK1 (0.69) | CDK1SRCPDGFRACCNE1CDK2 | |
| SCHEMBL5840468 | 0.83 | CDK1 (0.84) | CDK1SRCPDGFRACCNE1CDK2 | |
| SCHEMBL5840463 | 0.83 | CDK1 (0.84) | CDK1SRCPDGFRACCNE1CDK2 | |
| SCHEMBL6576120 | 0.82 | CDK1 (0.77) | CDK1PDGFRACCNE1CDK2PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6767906-B2 | INHIBIT P34CDC2/CYCLIN BCDC13 KINASE AND PROTEIN TYROSINE KINASE PP60C-SRC AND CAN BE USED FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES, FOR EXAMPLE CHEMOTHERAPY OF TUMOURS OR OSTEOPOROSIS. | NOVARTIS AG (CH) | 2004-07-27 | — | — | US | claimed |
| JP-2002537300-A | — | — | 2002-11-05 | — | — | JP | claimed |
| EP-1153024-A1 | 2-AMINO-6-ANILINO-PURINES AND THEIR USE AS MEDICAMENTS | Novartis AG (CH) | 2001-11-14 | — | — | EP | claimed |
| WO-2000049018-A1 | 2-AMINO-6-ANILINO-PURINES AND THEIR USE AS MEDICAMENTS | NOVARTIS AG (CH) | 2000-08-24 | — | — | WO | claimed |
| EP-1153024-B1 | 2-AMINO-6-ANILINO-PURINES AND THEIR USE AS MEDICAMENTS | NOVARTIS AG (CH) | 2004-04-28 | — | — | EP | disclosed |