Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TOP2A | P11388 | 11/20 | 0.43 |
| ▸ | TOP2B | Q02880 | 7/20 | 0.43 |
| ▸ | TOP1 | P11387 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.40 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | MATK | P42679 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20912654 | 0.90 | CYP3A4 (0.41) | CYP3A4CYP2C9TOP2ATOP2BTOP1 | |
| SCHEMBL7010194 | 0.88 | CACNA1F (0.51) | CYP3A4CYP2C9TOP2ATOP2BTOP1 | |
| SCHEMBL7014564 | 0.87 | CYP3A4 (0.46) | CYP3A4CYP2C9TOP2ATOP2BTOP1 | |
| SCHEMBL6580734 | 0.87 | CYP3A4 (0.56) | CYP3A4CYP2C9TOP2ATOP2BTOP1 | |
| SCHEMBL6576283 | 0.86 | TOP1 (0.43) | TOP2ATOP2BTOP1KCNH2CACNA1F | |
| SCHEMBL7011812 | 0.85 | KCNH2 (0.47) | CYP3A4CYP2C9TOP2ATOP2BTOP1 | |
| SCHEMBL7008959 | 0.85 | CYP3A4 (0.58) | CYP3A4CYP2C9TOP2ATOP2BTOP1 | |
| SCHEMBL19728826 | 0.84 | CYP3A4 (0.40) | CYP3A4CYP2C9TOP2ATOP2BTOP1 | |
| SCHEMBL19729472 | 0.84 | KDM4E (0.37) | CYP3A4CYP2C9TOP2ATOP2BTOP1 | |
| SCHEMBL19728827 | 0.84 | CYP3A4 (0.46) | CYP3A4CYP2C9TOP2ATOP2BTOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0897919-B1 | NOVEL PYRIDONECARBOXYLIC ACID DERIVATIVES OR SALTS THEREOF AND ANTIBACTERIAL AGENTS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | WAKUNAGA PHARMA CO LTD (JP) | 2004-06-16 | — | — | EP | disclosed |
| US-6211375-B1 | IMPROVED INTESTINAL ABSORPTION | WAKUNAGA PHARMACEUTICAL CO., LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| EP-0897919-A1 | NOVEL PYRIDONECARBOXYLIC ACID DERIVATIVES OR SALTS THEREOF AND ANTIBACTERIAL AGENTS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | WAKUNAGA PHARMACEUTICAL CO., LTD. (JP) | 1999-02-24 | — | — | EP | disclosed |