Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 9/20 | 0.77 |
| ▸ | BRDT | Q58F21 | 4/20 | 0.77 |
| ▸ | MAPK14 | Q16539 | 15/20 | 0.77 |
| ▸ | BRD2 | P25440 | 1/20 | 0.77 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.77 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.64 |
| ▸ | PRKACA | P17612 | 2/20 | 0.64 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.64 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.64 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.64 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.64 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.64 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.64 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.64 |
| ▸ | PRKCG | P05129 | 1/20 | 0.64 |
| ▸ | LCK | P06239 | 1/20 | 0.64 |
| ▸ | LYN | P07948 | 1/20 | 0.64 |
| ▸ | RET | P07949 | 1/20 | 0.64 |
| ▸ | PIM1 | P11309 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6578767 | 0.93 | BRD4 (0.80) | BRD4BRDTMAPK14BRD2BRD3 | |
| SCHEMBL6578659 | 0.90 | BRD4 (0.78) | BRD4BRDTMAPK14BRD2BRD3 | |
| SCHEMBL6576882 | 0.90 | MAPK14 (0.73) | BRD4BRDTMAPK14BRD2BRD3 | |
| SCHEMBL6579065 | 0.90 | MAPK14 (0.73) | BRD4BRDTMAPK14BRD2BRD3 | |
| SCHEMBL6576883 | 0.90 | MAPK14 (0.73) | BRD4BRDTMAPK14BRD2BRD3 | |
| SCHEMBL6577223 | 0.90 | MAPK14 (0.74) | BRD4BRDTMAPK14BRD2BRD3 | |
| SCHEMBL6579097 | 0.87 | MAPK14 (0.61) | BRD4BRDTMAPK14BRD2BRD3 | |
| SCHEMBL6579102 | 0.87 | MAPK14 (0.61) | BRD4BRDTMAPK14BRD2BRD3 | |
| SCHEMBL6579234 | 0.87 | MAPK14 (0.61) | BRD4BRDTMAPK14BRD2BRD3 | |
| SCHEMBL22730405 | 0.87 | BRD4 (1.00) | BRD4BRDTMAPK14BRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0961618-B1 | 5-Pyrimidinyl-4-yl-Imidazole Derivate zur Behandlung von CSBP/RK/p38 vermittelten Erkrankungen | SMITHKLINE BEECHAM CORP (US) | 2004-08-04 | — | — | EP | claimed |
| US-6369068-B1 | Amino substituted pyrimidine containing compounds | SMITHKLINE BEECHAM CORPORATION | 2002-04-09 | — | — | US | claimed |
| US-6369068-B1 | Amino substituted pyrimidine containing compounds | SMITHKLINE BEECHAM CORPORATION | 2002-04-09 | — | — | US | disclosed |