Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.68 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.68 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.68 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.68 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.68 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.68 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.68 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.68 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.68 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.68 |
| ▸ | EGFR | P00533 | 2/20 | 0.68 |
| ▸ | LCK | P06239 | 2/20 | 0.68 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.68 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.68 |
| ▸ | PRKCA | P17252 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | RAF1 | P04049 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6949303 | 0.90 | MAPK14 (0.56) | MAPK14CSNK1DMAPK13MAPK12MAPK11 | |
| SCHEMBL4908397 | 0.89 | MAPK14 (0.72) | MAPK14CSNK1DMAPK13MAPK12MAPK11 | |
| SCHEMBL4908399 | 0.89 | MAPK14 (0.72) | MAPK14CSNK1DMAPK13MAPK12MAPK11 | |
| SCHEMBL6578852 | 0.85 | MAPK14 (0.66) | MAPK14CSNK1DMAPK13MAPK12MAPK11 | |
| SCHEMBL4917980 | 0.82 | MAPK14 (0.81) | MAPK14CSNK1DMAPK13MAPK12MAPK11 | |
| SCHEMBL7772152 | 0.82 | MAPK14 (0.82) | MAPK14CSNK1DMAPK13MAPK12MAPK11 | |
| SCHEMBL4912960 | 0.81 | MAPK14 (1.00) | MAPK14CSNK1DMAPK13MAPK12MAPK11 | |
| SCHEMBL24170876 | 0.81 | MAPK14 (1.00) | MAPK14CSNK1DMAPK13MAPK12MAPK11 | |
| SCHEMBL173596 | 0.81 | MAPK14 (1.00) | MAPK14CSNK1DMAPK13MAPK12MAPK11 | |
| SCHEMBL30290594 | 0.81 | MAPK14 (1.00) | MAPK14CSNK1DMAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889726-B1 | NOVEL CYCLOALKYL SUBSTITUTED IMIDAZOLES | SMITHKLINE BEECHAM CORP (US) | 2004-09-15 | — | — | EP | disclosed |
| US-6329526-B1 | Cycloalkyl substituted imidazoles | SMITHKLINE BEECHAM CORPORATION | 2001-12-11 | — | — | US | disclosed |
| US-6251914-B1 | TREATING CYTOKINE MEDIATED DISEASES | SMITHKLINE BEECHAM CORPORATION | 2001-06-26 | — | — | US | disclosed |