Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.46 |
| ▸ | GRN | P28799 | 1/20 | 0.44 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL660095 | 0.90 | MAPK14 (0.48) | GRNSORT1MAPK14MAPK13MAPK12 | |
| SCHEMBL659101 | 0.88 | TRPV1 (0.42) | TRPV1GRNSORT1MAPK14MAPK13 | |
| SCHEMBL657576 | 0.83 | TRPV1 (0.38) | TRPV1GRNSORT1MAPK14MAPK13 | |
| SCHEMBL659630 | 0.80 | KLKB1 (0.49) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL659071 | 0.80 | KCNJ6 (0.49) | TRPV1GAA | |
| SCHEMBL657753 | 0.80 | MAPK14 (0.43) | TRPV1GRNSORT1MAPK14MAPK13 | |
| SCHEMBL287372 | 0.78 | TRPV1 (0.49) | TRPV1GRNSORT1MAPK14MAPK13 | |
| SCHEMBL25510561 | 0.76 | TRPV1 (0.47) | TRPV1GRNSORT1MAPK14MAPK13 | |
| SCHEMBL657732 | 0.76 | TRPV1 (0.44) | TRPV1GAA | |
| SCHEMBL2787544 | 0.73 | GRN (0.76) | TRPV1GRNSORT1MAPK14MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046301-A1 | Substituted Cyclic Carboxamide and Urea Derivatives as Ligands of the Vanilloid Receptor | GRUENENTHAL GMBH (DE) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046301-A1 | Substituted Cyclic Carboxamide and Urea Derivatives as Ligands of the Vanilloid Receptor | TRPV1, CNR1, CNR2 | TRPV1 1/4885GRN 4603/4885SORT1 4801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.