Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | TACR2 | P21452 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6579943 | 1.00 | MEN1 (0.33) | MEN1KMT2AHCRTR2ALDH1A1LMNA | |
| SCHEMBL6579463 | 0.90 | TACR2 (0.33) | HCRTR2ALDH1A1LMNAHPGDATM | |
| SCHEMBL8142664 | 0.90 | TACR2 (0.33) | HCRTR2ALDH1A1LMNAHPGDATM | |
| SCHEMBL6577365 | 0.90 | TACR2 (0.33) | HCRTR2ALDH1A1LMNAHPGDATM | |
| SCHEMBL6579201 | 0.88 | HCRTR2 (0.33) | HCRTR2ALDH1A1LMNAHPGDATM | |
| SCHEMBL6579663 | 0.88 | HCRTR2 (0.33) | HCRTR2ALDH1A1LMNAHPGDATM | |
| SCHEMBL6577333 | 0.77 | TACR2 (0.32) | TACR2 | |
| SCHEMBL6577217 | 0.77 | TACR2 (0.32) | TACR2 | |
| SCHEMBL6579767 | 0.75 | TDP1 (0.32) | MEN1KMT2AALDH1A1TACR2 | |
| SCHEMBL6581521 | 0.74 | UTS2R (0.38) | KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994876-B1 | QUATERNARY AMMONIUM COMPOUNDS AS TACHYKININ ANTAGONISTS | PFIZER LTD (GB) | 2004-09-08 | — | — | EP | disclosed |
| US-6380396-B1 | CHEMICAL INTERMEDIATES FOR ANTIINFLAMMATORY AGENTS | PFIZER INC. | 2002-04-30 | — | — | US | disclosed |
| US-6207678-B1 | USED FOR TREATING INFLAMMATORY DISEASE SUCH AS ARTHRITIS, PSORIASIS, ASTHMA OR INFLAMMATORY BOWEL DISEASE, CENTRAL NERVOUS SYSTEM DISORDER SUCH AS ANXIETY, DEPRESSION, DEMENTIA OR PSYCHOSIS, GASTROINTESTINAL DISORDERS | PFIZER INC | 2001-03-27 | — | — | US | disclosed |