Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 7/20 | 0.62 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 17/20 | 0.61 |
| ▸ | BRD2 | P25440 | 1/20 | 0.59 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | RAF1 | P04049 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | PRKCA | P17252 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | FRK | P42685 | 1/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.50 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6576824 | 1.00 | BRD4 (0.62) | BRD4BRDTMAPK14BRD2BRD3 | |
| SCHEMBL6576610 | 1.00 | BRD4 (0.62) | BRD4BRDTMAPK14BRD2BRD3 | |
| SCHEMBL6579234 | 0.93 | MAPK14 (0.61) | BRD4BRDTMAPK14BRD2BRD3 | |
| SCHEMBL6579097 | 0.93 | MAPK14 (0.61) | BRD4BRDTMAPK14BRD2BRD3 | |
| SCHEMBL6579102 | 0.93 | MAPK14 (0.61) | BRD4BRDTMAPK14BRD2BRD3 | |
| SCHEMBL6581214 | 0.90 | MAPK14 (0.73) | BRD4BRDTMAPK14BRD2BRD3 | |
| SCHEMBL6581217 | 0.90 | MAPK14 (0.73) | BRD4BRDTMAPK14BRD2BRD3 | |
| SCHEMBL6576809 | 0.90 | MAPK14 (0.73) | BRD4BRDTMAPK14BRD2BRD3 | |
| SCHEMBL6577075 | 0.89 | MAPK14 (0.60) | BRD4BRDTMAPK14BRD2BRD3 | |
| SCHEMBL6579817 | 0.89 | MAPK14 (0.60) | BRD4BRDTMAPK14BRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0961618-B1 | 5-Pyrimidinyl-4-yl-Imidazole Derivate zur Behandlung von CSBP/RK/p38 vermittelten Erkrankungen | SMITHKLINE BEECHAM CORP (US) | 2004-08-04 | — | — | EP | claimed |