Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL659033 | 1.00 | PARP1 (0.63) | PARP1PARP2 | |
| SCHEMBL658961 | 0.99 | PARP1 (0.62) | PARP1PARP2 | |
| SCHEMBL657658 | 0.99 | PARP1 (0.62) | PARP1PARP2 | |
| SCHEMBL655802 | 0.98 | PARP1 (0.60) | PARP1PARP2 | |
| SCHEMBL658813 | 0.98 | PARP1 (0.60) | PARP1PARP2 | |
| SCHEMBL657487 | 0.97 | PARP1 (0.62) | PARP1PARP2 | |
| SCHEMBL658577 | 0.93 | PARP1 (0.54) | PARP1PARP2 | |
| SCHEMBL658317 | 0.87 | PARP1 (0.69) | PARP1PARP2 | |
| SCHEMBL655470 | 0.87 | PARP1 (0.69) | PARP1PARP2 | |
| SCHEMBL658099 | 0.86 | PARP1 (0.70) | PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067613-B2 | Benzimidazole poly(ADP ribose)polymerase inhibitors | ABBOTT LABORATORIES (US) | 2011-11-29 | — | — | US | claimed |
| EP-2183248-A2 | BENZIMIDAZOLE POLY (ADP RIBOSE) POLYMERASE INHIBITORS | Abbott Laboratories (US) | 2010-05-12 | — | — | EP | claimed |
| US-20090030016-A1 | BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-01-29 | — | — | US | claimed |
| WO-2009012280-A2 | BENZIMIDAZOLE POLY(ADP-RIBOSE)POLYMERASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-01-22 | — | — | WO | claimed |
| US-20120046303-A1 | BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS | ABBOTT LABORATORIES (US) | 2012-02-23 | — | — | US | disclosed |
| US-8067613-B2 | Benzimidazole poly(ADP ribose)polymerase inhibitors | ABBOTT LABORATORIES (US) | 2011-11-29 | — | — | US | disclosed |
| EP-2183248-A2 | BENZIMIDAZOLE POLY (ADP RIBOSE) POLYMERASE INHIBITORS | Abbott Laboratories (US) | 2010-05-12 | — | — | EP | disclosed |
| US-20090030016-A1 | BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-01-29 | — | — | US | disclosed |
| WO-2009012280-A2 | BENZIMIDAZOLE POLY(ADP-RIBOSE)POLYMERASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030016-A1 | BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS | PARP1, PARP2, PARP3 | PARP1 1/4885PARP2 2/4885 |
| US-20120046303-A1 | BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS | PARP1, PARP2, PARP3 | PARP1 1/4885PARP2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.