Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 10/20 | 0.35 |
| ▸ | IDO1 | P14902 | 4/20 | 0.35 |
| ▸ | NAMPT | P43490 | 5/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16901677 | 0.75 | NAMPT (0.40) | DYRK1AKDM4EHTTTDO2IDO1 | |
| SCHEMBL19336862 | 0.75 | NAMPT (0.35) | DYRK1AKDM4EHTTNAMPTCYP2C9 | |
| SCHEMBL22791609 | 0.75 | NAMPT (0.38) | TDO2IDO1NAMPTCYP2C9CYP2A6 | |
| SCHEMBL18660625 | 0.75 | HASPIN (0.35) | KDM4ENPC1CYP1A2CYP2C19HTT | |
| SCHEMBL1763648 | 0.75 | NAMPT (0.35) | DYRK1AKDM4EHTTNAMPTCYP2C9 | |
| SCHEMBL2629271 | 0.75 | MAPT (0.51) | DYRK1AKDM4ENPC1CYP1A2CYP2C19 | |
| SCHEMBL30770758 | 0.75 | KDM4E (0.56) | KDM4ENAMPTCYP2C9CYP2A6 | |
| SCHEMBL8627966 | 0.73 | NPC1 (0.37) | NPC1CYP2C19RAB9AIDO1NAMPT | |
| SCHEMBL5955066 | 0.72 | NPC1 (0.46) | NPC1CYP2C19RAB9AIDO1NAMPT | |
| SCHEMBL6343739 | 0.72 | NAMPT (0.47) | NPC1NAMPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8378104-B2 | 7-aminofuropyridine derivatives | OSI Pharmaceuticals, LLC (US) | 2013-02-19 | — | — | US | disclosed |
| US-20120046267-A1 | 7-AMINOFUROPYRIDINE DERIVATIVES | OSI PHARMACEUTICALS, INC. | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046267-A1 | 7-AMINOFUROPYRIDINE DERIVATIVES | MAP3K5, STK17A, MAPKAPK5 | CDK9 232/4885DYRK1A 2154/4885KDM4E 117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.