Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 17/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583938 | 0.92 | NAMPT (0.67) | NAMPT | |
| SCHEMBL6902914 | 0.92 | NAMPT (0.73) | NAMPT | |
| SCHEMBL6583049 | 0.91 | NAMPT (0.60) | NAMPTKDM4EOPRM1OPRD1ALDH1A1 | |
| SCHEMBL6790569 | 0.91 | NAMPT (0.66) | NAMPTALDH1A1 | |
| SCHEMBL6583098 | 0.90 | NAMPT (0.66) | NAMPT | |
| SCHEMBL6582292 | 0.90 | NAMPT (0.64) | NAMPT | |
| SCHEMBL6580507 | 0.90 | NAMPT (0.65) | NAMPT | |
| SCHEMBL6582182 | 0.88 | NAMPT (0.63) | NAMPT | |
| SCHEMBL6584636 | 0.87 | NAMPT (0.87) | NAMPT | |
| SCHEMBL6580435 | 0.84 | NAMPT (0.71) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155012-B1 | ANTI-CANCER DIHYDROQUINAZOLINE DERIVATIVES | CANCER REC TECH LTD (GB) | 2004-04-14 | — | — | EP | disclosed |
| US-6699861-B1 | ANTI-CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2004-03-02 | — | — | US | disclosed |
| EP-1155012-A1 | ANTI-CANCER DIHYDROQUINAZOLINE DERIVATIVES | Cancer Research Ventures Limited (GB) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000050417-A1 | ANTI-CANCER DIHYDROQUINAZOLINE DERIVATIVES | CANCER RESEARCH VENTURES LIMITED (GB) | 2000-08-31 | — | — | WO | disclosed |