Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 6/20 | 0.41 |
| ▸ | NCEH1 | Q6PIU2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4670237 | 0.89 | PTPN1 (0.42) | PTPN1NCEH1MEN1KMT2AHCRTR1 | |
| SCHEMBL4670774 | 0.87 | PTPN1 (0.52) | PTPN1NCEH1MEN1KMT2AHCRTR1 | |
| SCHEMBL4670162 | 0.82 | PTPN1 (0.45) | PTPN1NCEH1MEN1KMT2AHCRTR1 | |
| SCHEMBL4670612 | 0.80 | PTPN1 (0.55) | PTPN1NCEH1HCRTR1RAB9A | |
| SCHEMBL4670153 | 0.76 | PTPN1 (0.55) | PTPN1NCEH1HCRTR1RAB9AALDH1A1 | |
| SCHEMBL4670772 | 0.74 | PTPN1 (0.53) | PTPN1NCEH1ABCG2 | |
| SCHEMBL4670236 | 0.74 | PTPN1 (0.46) | PTPN1NCEH1MEN1KMT2AHCRTR1 | |
| SCHEMBL4670647 | 0.74 | PTPN1 (0.51) | PTPN1NCEH1MEN1KMT2ARAB9A | |
| SCHEMBL4670288 | 0.72 | PTPN1 (0.59) | PTPN1NCEH1MEN1KMT2AHCRTR1 | |
| SCHEMBL4670735 | 0.72 | PTPN1 (0.63) | PTPN1NCEH1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397341-A1 | 6-(ARYL-AMIDO OR ARYL-AMIDOMETHYL)-NAPHTHALEN-2-YLOXY-ACIDIC DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1) | Wyeth (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2003000649-A1 | 6-(ARYL-AMIDO OR ARYL-AMIDOMETHYL)-NAPHTHALEN-2-YLOXY-ACIDIC DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1) | WYETH (US) | 2003-01-03 | — | — | WO | disclosed |