Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 7/20 | 1.00 |
| ▸ | MAPK14 | Q16539 | 6/20 | 1.00 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.70 |
| ▸ | AXL | P30530 | 2/20 | 0.67 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | ALPL | P05186 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | IDO1 | P14902 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | TTK | P33981 | 1/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31060683 | 1.00 | MAPK10 (1.00) | MAPK10MAPK14MAPK8AXLMAP2K4 | |
| Hydrochloric Acid SCHEMBL6369462 | 0.98 | MAPK10 (0.97) | MAPK10MAPK14MAPK8AXLMAP2K4 | |
| Hydrochloric Acid SCHEMBL6370716 | 0.90 | MAPK10 (0.81) | MAPK10MAPK14MAPK8AXLMAP2K4 | |
| Hydrochloric Acid SCHEMBL6371107 | 0.86 | MAPK10 (0.75) | MAPK10MAPK14MAPK8AXLMAP2K4 | |
| Hydrochloric Acid SCHEMBL6370649 | 0.86 | MAPK10 (0.75) | MAPK10MAPK14MAPK8AXLMAP2K4 | |
| Hydrochloric Acid SCHEMBL6375871 | 0.84 | MAPK10 (0.71) | MAPK10MAPK14MAPK8AXLMAP2K4 | |
| SCHEMBL6370549 | 0.83 | MAPK10 (0.70) | MAPK10MAPK14MAPK8AXLMAP2K4 | |
| Hydrochloric Acid SCHEMBL6370086 | 0.83 | MAPK10 (0.70) | MAPK10MAPK14MAPK8AXLMAP2K4 | |
| SCHEMBL30338305 | 0.82 | MAPK10 (0.69) | MAPK10MAPK14MAPK8AXLKDM4E | |
| Hydrochloric Acid SCHEMBL6370576 | 0.82 | MAPK10 (0.68) | MAPK10MAPK14MAPK8AXLMAP2K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476432-A1 | THERAPEUTIC SUBSTITUTED INDAZOLE DERIVATIVES | AstraZeneca AB (SE) | 2004-11-17 | — | — | EP | disclosed |
| WO-2003068754-A1 | THERAPEUTIC SUBSTITUTED INDAZOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-08-21 | — | — | WO | disclosed |