Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 13/20 | 0.61 |
| ▸ | CYSLTR2 | Q9NS75 | 10/20 | 0.61 |
| ▸ | GPBAR1 | Q8TDU6 | 7/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | GMNN | O75496 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6581010 | 0.93 | CYSLTR2 (0.62) | CYSLTR1CYSLTR2GPBAR1ALOX5 | |
| SCHEMBL6584606 | 0.87 | CYSLTR1 (0.51) | CYSLTR1CYSLTR2GPBAR1MAPK1TP53 | |
| SCHEMBL6091295 | 0.87 | CYSLTR1 (0.65) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL6092416 | 0.83 | CYSLTR1 (0.58) | CYSLTR1CYSLTR2GPBAR1MAPK1TP53 | |
| SCHEMBL14021575 | 0.83 | CYSLTR1 (0.65) | CYSLTR1CYSLTR2GPBAR1MAPK1TP53 | |
| SCHEMBL10544491 | 0.82 | CYSLTR1 (0.66) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL6090813 | 0.80 | CYSLTR1 (0.69) | CYSLTR1CYSLTR2GPBAR1ALOX5 | |
| SCHEMBL6091833 | 0.80 | CYSLTR1 (0.54) | CYSLTR1CYSLTR2GPBAR1MAPK1TP53 | |
| SCHEMBL5725146 | 0.79 | CYSLTR1 (0.67) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL6090484 | 0.79 | CYSLTR1 (0.73) | CYSLTR1CYSLTR2GPBAR1MAPK1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784052-B1 | Quinoline derivatives as antagonists of leukotriene d4, compositions containing the same and processes for their preparation | AVENTIS HOLDINGS INC (US) | 2004-09-01 | — | — | EP | disclosed |
| EP-0784052-A1 | Quinoline derivatives as antagonists of leukotriene d4, compositions containing the same and processes for their preparation | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1997-07-16 | — | — | EP | disclosed |
| WO-1989012628-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-12-28 | — | — | WO | disclosed |
| EP-0348155-A1 | Quinoline derivatives as antagonists of leukotriene D4, compositions containing the same and processes for their preparation | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1989-12-27 | — | — | EP | disclosed |