Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 9/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | MAP3K8 | P41279 | 4/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.40 |
| ▸ | FLT1 | P17948 | 4/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15868927 | 0.96 | FGFR1 (0.45) | PDPK1CDK2MAP3K8FGFR1FLT1 | |
| SCHEMBL3535364 | 0.95 | FLT3 (0.42) | PDPK1FGFR1FLT1 | |
| SCHEMBL5866790 | 0.90 | FLT3 (0.39) | PDPK1FGFR1FLT1 | |
| SCHEMBL3541030 | 0.87 | ITK (0.39) | PDPK1CDK2CDK4CCNA2CCND1 | |
| SCHEMBL3532400 | 0.87 | FGFR1 (0.54) | PDPK1CDK2FGFR1FLT1PAK4 | |
| SCHEMBL3538576 | 0.84 | CDK4 (0.48) | CDK2CDK4CCNA2CCND1CCND3 | |
| SCHEMBL3539176 | 0.83 | CDK4 (0.42) | CDK2CDK4CCNA2CCND1CCND3 | |
| SCHEMBL3537078 | 0.83 | FGFR1 (0.43) | PDPK1CDK2CDK4CCNA2CCND1 | |
| SCHEMBL3540634 | 0.83 | PDPK1 (0.34) | PDPK1CDK2CDK4CCNA2CCND1 | |
| SCHEMBL3542676 | 0.83 | FGFR1 (0.48) | PDPK1CDK2MAP3K8FGFR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401831-A1 | INDAZOLE BENZIMIDAZOLE COMPOUNDS AS TYROSINE AND SERINE/THREONINE KINASE INHIBITORS | CHIRON CORPORATION (US) | 2004-03-31 | — | — | EP | disclosed |
| WO-2003004488-A1 | INDAZOLE BENZIMIDAZOLE COMPOUNDS AS TYROSINE AND SERINE/THREONINE KINASE INHIBITORS | CHIRON CORPORATION (US) | 2003-01-16 | — | — | WO | disclosed |