Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.70 |
| ▸ | MAPK13 | O15264 | 10/20 | 0.70 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.70 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.70 |
| ▸ | GCGR | P47871 | 2/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | FRK | P42685 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.45 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.45 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171878 | 1.00 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL6582427 | 0.89 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL6177031 | 0.85 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5640796 | 0.84 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5637234 | 0.82 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5139712 | 0.82 | MAPK14 (0.66) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5639664 | 0.81 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL6582407 | 0.81 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL6169935 | 0.80 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL27527808 | 0.79 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1291984-C | 2-thio-substituted imidazole derivatives and use therof in pharmaceutical industry | MERCKLE GMBH (DE) | 2006-12-27 | — | — | CN | disclosed |
| EP-1362045-B1 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THE USE THEREOF IN THE PHARMACEUTICAL INDUSTRY | MERCKLE GMBH (DE) | 2004-11-17 | — | — | EP | disclosed |
| CN-1511149-A | 2-thio-substituted imidazole derivatives and pharmaceutical use thereof | ��Ĭ���� | 2004-07-07 | — | — | CN | disclosed |