Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK3 | O43781 | 1/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.57 |
| ▸ | PIM1 | P11309 | 1/20 | 0.57 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.57 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.57 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.57 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.57 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.57 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.57 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.57 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.57 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.57 |
| ▸ | PARP1 | P09874 | 7/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584116 | 0.95 | DYRK3 (0.56) | DYRK3MAP4K4PIM1RPS6KB1CSNK2A1 | |
| SCHEMBL6579124 | 0.88 | MAP4K4 (0.75) | DYRK3MAP4K4PIM1RPS6KB1CSNK2A1 | |
| SCHEMBL6581364 | 0.86 | MAP4K4 (0.62) | DYRK3MAP4K4PIM1RPS6KB1CSNK2A1 | |
| SCHEMBL6584057 | 0.85 | PIM1 (0.58) | DYRK3MAP4K4PIM1RPS6KB1CSNK2A1 | |
| SCHEMBL3580297 | 0.85 | MAP4K4 (0.77) | DYRK3MAP4K4PIM1RPS6KB1CSNK2A1 | |
| SCHEMBL6380066 | 0.83 | PARP1 (0.55) | PIM1PIM3AURKBPARP1 | |
| SCHEMBL6383675 | 0.82 | PARP1 (0.57) | PIM1PIM3AURKBPARP1DHODH | |
| SCHEMBL6584213 | 0.82 | DYRK3 (0.50) | DYRK3MAP4K4PIM1RPS6KB1CSNK2A1 | |
| SCHEMBL6578530 | 0.81 | PARP1 (0.67) | PARP1DHODH | |
| SCHEMBL6384304 | 0.80 | PARP1 (0.45) | PARP1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391457-B1 | Substituted 2-Phenylbenzimidazoles and their use as PARP inhibitors | ABBVIE DEUTSCHLAND (DE) | 2013-12-25 | — | — | EP | disclosed |
| EP-1127052-B1 | SUBSTITUTED 2-PHENYLBENZIMIDAZOLES, THE PRODUCTION THEREOF AND THEIR USE | ABBOTT GMBH & CO KG (DE) | 2004-12-08 | — | — | EP | disclosed |
| EP-1391457-A1 | Substituted 2-Phenylbenzimidazoles and their use as PARP inhibitors | Abbott GmbH & Co. KG (DE) | 2004-02-25 | — | — | EP | disclosed |
| EP-1127052-A1 | SUBSTITUTED 2-PHENYLBENZIMIDAZOLES, THE PRODUCTION THEREOF AND THEIR USE | BASF AKTIENGESELLSCHAFT (DE) | 2001-08-29 | — | — | EP | disclosed |
| WO-2000026192-A1 | SUBSTITUTED 2-PHENYLBENZIMIDAZOLES, THE PRODUCTION THEREOF AND THEIR USE | BASF AKTIENGESELLSCHAFT (DE) | 2000-05-11 | — | — | WO | disclosed |