Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 17/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | CDK8 | P49336 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | CDK7 | P50613 | 1/20 | 0.52 |
| ▸ | CDK9 | P50750 | 1/20 | 0.52 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4021088 | 0.78 | TRPV1 (0.67) | TRPV1KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4019250 | 0.77 | TRPV1 (0.65) | TRPV1KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4023915 | 0.74 | TRPV1 (0.80) | TRPV1CHEK1PIM1CDK8GSK3B | |
| SCHEMBL4021176 | 0.73 | TRPV1 (0.72) | TRPV1KDM4EMAPTCHEK1PIM1 | |
| SCHEMBL3937023 | 0.71 | TRPV1 (0.61) | TRPV1KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3937017 | 0.71 | TRPV1 (0.61) | TRPV1KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4023494 | 0.71 | TRPV1 (0.76) | TRPV1KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3943228 | 0.71 | TRPV1 (0.58) | TRPV1KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4029235 | 0.71 | TRPV1 (0.60) | TRPV1KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3943231 | 0.71 | TRPV1 (0.58) | TRPV1KDM4EALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478363-A1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | Abbott Laboratories (US) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003070247-A1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LABORATORIES (US) | 2003-08-28 | — | — | WO | disclosed |