Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 2/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.43 |
| ▸ | NMT1 | P30419 | 5/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6580533 | 0.99 | ACP1 (0.45) | ACP1NR1H2NR1H3NPC1RAB9A | |
| SCHEMBL6581290 | 0.88 | NR1H2 (0.50) | NR1H2NR1H3NPC1RAB9ATNK2 | |
| Hydrochloric Acid SCHEMBL6580743 | 0.87 | NR1H2 (0.49) | NR1H2NR1H3NPC1RAB9ATNK2 | |
| SCHEMBL6580791 | 0.87 | TNK2 (0.43) | NR1H2NR1H3NPC1RAB9ATNK2 | |
| SCHEMBL6578223 | 0.86 | NR1H2 (0.47) | ACP1NR1H2NR1H3TNK2AVPR1B | |
| Hydrochloric Acid SCHEMBL6583998 | 0.86 | TNK2 (0.42) | NR1H2NR1H3NPC1RAB9ATNK2 | |
| SCHEMBL6578579 | 0.85 | NR1H3 (0.49) | ACP1NR1H2NR1H3NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL6584058 | 0.85 | NR1H2 (0.47) | ACP1NR1H2NR1H3TNK2AVPR1B | |
| Hydrochloric Acid SCHEMBL6582636 | 0.85 | NR1H3 (0.47) | ACP1NR1H2NR1H3TNK2AVPR1B | |
| Hydrochloric Acid SCHEMBL6581120 | 0.85 | NR1H3 (0.47) | ACP1NR1H2NR1H3TNK2AVPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070708-B1 | Triazole derivatives | HOFFMANN LA ROCHE (CH) | 2004-01-14 | — | — | EP | claimed |
| US-6265426-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-07-24 | — | — | US | claimed |
| EP-1070708-A1 | Triazole and imidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-01-24 | — | — | EP | claimed |
| EP-1070708-B1 | Triazole derivatives | HOFFMANN LA ROCHE (CH) | 2004-01-14 | — | — | EP | disclosed |
| US-6265426-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-07-24 | — | — | US | disclosed |
| EP-1070708-A1 | Triazole and imidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-01-24 | — | — | EP | disclosed |