Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.48 |
| ▸ | PDE2A | O00408 | 4/20 | 0.48 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 6/20 | 0.47 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5421328 | 0.90 | PDE3B (0.50) | PDE3BPDE3APDE2APPARGPPARA | |
| SCHEMBL6582267 | 0.88 | PDE3B (0.48) | PDE3BPDE3APDE2APPARGPPARA | |
| SCHEMBL2327181 | 0.86 | PPARG (0.52) | PDE3BPDE3APDE2APPARGPPARA | |
| SCHEMBL5417074 | 0.85 | PPARG (0.49) | PDE3BPDE3APDE2APPARGPPARA | |
| SCHEMBL2213545 | 0.84 | PPARG (0.46) | PDE3BPDE3APDE2APPARGPPARA | |
| SCHEMBL2329776 | 0.84 | SIRT2 (0.51) | PDE3BPDE3APDE2APPARGPPARA | |
| SCHEMBL6370131 | 0.83 | PDE3B (0.44) | PDE3BPDE3APDE2APPARGPPARA | |
| SCHEMBL5414904 | 0.82 | AR (0.50) | PDE3BPDE3APDE2APPARGPPARA | |
| SCHEMBL6369472 | 0.82 | PDE3B (0.46) | PDE3BPDE3APDE2APPARGPPARA | |
| SCHEMBL6167194 | 0.82 | DPP4 (0.47) | PDE3BPDE3APDE2APPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404656-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATING MICROGLIA-ACTIVATION ASSOCIATED DISEASES SUCH AS INFLAMMATORY, ALLERGIC, INFECTIOUS OR AUTOIMMUNE DISEASES | SCHERING AKTIENGESELLSCHAFT (DE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003006438-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATING MICROGLIA-ACTIVATION ASSOCIATED DISEASES SUCH AS INFLAMMATORY, ALLERGIC, INFECTIOUS OR AUTOIMMUNE DISEASES | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-01-23 | — | — | WO | disclosed |