Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 12/20 | 0.58 |
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.58 |
| ▸ | CYSLTR2 | Q9NS75 | 8/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583516 | 0.94 | GPBAR1 (0.54) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL6089253 | 0.90 | CYSLTR1 (0.59) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL6088437 | 0.89 | CYSLTR1 (0.54) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL6583639 | 0.88 | CYSLTR1 (0.54) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL6583782 | 0.88 | CYSLTR1 (0.62) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL6091833 | 0.87 | CYSLTR1 (0.54) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL10635560 | 0.87 | CYSLTR1 (0.71) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL6582739 | 0.86 | CYSLTR1 (0.62) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL6582234 | 0.84 | CYSLTR1 (0.61) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL6089445 | 0.84 | CYSLTR1 (0.57) | CYSLTR1GPBAR1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784052-B1 | Quinoline derivatives as antagonists of leukotriene d4, compositions containing the same and processes for their preparation | AVENTIS HOLDINGS INC (US) | 2004-09-01 | — | — | EP | disclosed |
| EP-0784052-A1 | Quinoline derivatives as antagonists of leukotriene d4, compositions containing the same and processes for their preparation | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1997-07-16 | — | — | EP | disclosed |
| WO-1989012628-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-12-28 | — | — | WO | disclosed |