Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.61 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.61 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 11/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.53 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.53 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.52 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11203042 | 0.99 | CHRM2 (0.60) | CHRM2CHRM4CHRM1CHRM3OPRM1 | |
| SCHEMBL2636603 | 0.91 | CHRM1 (0.57) | CHRM2CHRM4CHRM1CHRM3OPRM1 | |
| SCHEMBL2636476 | 0.91 | CHRM1 (0.57) | CHRM2CHRM4CHRM1CHRM3OPRM1 | |
| SCHEMBL2636477 | 0.91 | CHRM1 (0.57) | CHRM2CHRM4CHRM1CHRM3OPRM1 | |
| SCHEMBL4084782 | 0.85 | CHRM1 (0.76) | CHRM2CHRM4CHRM1CHRM3OPRM1 | |
| SCHEMBL22605476 | 0.85 | CHRM1 (0.58) | CHRM2CHRM4CHRM1CHRM3OPRM1 | |
| SCHEMBL3142425 | 0.85 | CHRM1 (0.81) | CHRM2CHRM4CHRM1CHRM3OPRM1 | |
| SCHEMBL31285882 | 0.85 | CHRM1 (0.58) | CHRM2CHRM4CHRM1CHRM3OPRM1 | |
| SCHEMBL3146496 | 0.83 | CHRM2 (0.83) | CHRM2CHRM4CHRM1CHRM3OPRM1 | |
| SCHEMBL15575953 | 0.83 | CHRM2 (0.42) | CHRM2CHRM4CHRM1CHRM3OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023011513-A1 | SHP2 INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND APPLICATION THEREOF | 北京泰德制药股份有限公司 | 2023-02-09 | — | — | WO | disclosed |
| EP-0990653-B1 | 2-OXOIMIDAZOLE DERIVATIVES | BANYU PHARMA CO LTD (JP) | 2004-09-15 | — | — | EP | disclosed |
| US-6258825-B1 | ANALGESIC, A RELIEVER AGAINST TOLERANCE TO A NARCOTIC ANALGESIC REPRESENTED BY MORPHINE, REMEDY FOR PARKINSONISM, A REMEDY FOR CHOREA, AN ANTIDEPRESSANT, A REMEDY FOR DIABETES INSIPIDUS, A REMEDY FOR POLYURIA, OR HYPOTENSION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2001-07-10 | — | — | US | disclosed |
| EP-0990653-A1 | 2-OXOIMIDAZOLE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2000-04-05 | — | — | EP | disclosed |