Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 6/20 | 0.68 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.68 |
| ▸ | HPN | P05981 | 2/20 | 0.68 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.68 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.68 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.68 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.68 |
| ▸ | F2 | P00734 | 4/20 | 0.47 |
| ▸ | DCUN1D1 | Q96GG9 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | CCR3 | P51677 | 1/20 | 0.46 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.45 |
| ▸ | UBE2M | P61081 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6582627 | 1.00 | F10 (0.68) | F10PRSS1HPNPRSS2PRSS3 | |
| SCHEMBL6585567 | 0.99 | F10 (0.69) | F10PRSS1HPNPRSS2PRSS3 | |
| SCHEMBL6585586 | 0.86 | F10 (0.48) | F10PRSS1HPNPRSS2PRSS3 | |
| SCHEMBL6590427 | 0.86 | F10 (0.52) | F10PRSS1HPNPRSS2PRSS3 | |
| SCHEMBL7248310 | 0.85 | F10 (0.46) | F10PRSS1HPNPRSS2PRSS3 | |
| SCHEMBL6588093 | 0.83 | TP53 (0.51) | F10PRSS1HPNPRSS2PRSS3 | |
| SCHEMBL6584416 | 0.83 | CCR3 (0.62) | DCUN1D1KMT2AALDH1A1POLBCCR3 | |
| SCHEMBL6583982 | 0.82 | CCR3 (0.64) | DCUN1D1KMT2AALDH1A1POLBCCR3 | |
| SCHEMBL6615128 | 0.81 | F10 (0.44) | F10PRSS1HPNPRSS2PRSS3 | |
| SCHEMBL6587317 | 0.80 | F10 (0.43) | F10PRSS1HPNPRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0960104-B1 | N-(AMIDINOPHENYL)-N'-(SUBST.)-3H-2,4-BENZODIAZEPIN-3-ONE DERIVATIVES AS FACTOR XA INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2004-06-16 | — | — | EP | disclosed |
| US-6521614-B1 | Anticoagulant agents for treatment and prevention of thromboembolic disorders | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-02-18 | — | — | US | disclosed |
| EP-0960104-A1 | N-(AMIDINOPHENYL)-N'-(SUBST.)-3H-2,4-BENZODIAZEPIN-3-ONE DERIVATIVES AS FACTOR XA INHIBITORS | Du Pont Pharmaceuticals Company (US) | 1999-12-01 | — | — | EP | disclosed |
| US-5925635-A | 2-(OXO-1,3-PERHYDRODIAZEPINES OR 3-OXO-2,3,4,5-TETRAHYDRO-1H-2,4-BENZODIAZEPINES; ANTICOAGULANTS; ENZYME INHIBITORS OF SERINE PROTEASE THROMBIN, KALLIKREIN AND PLASMIN; NERVOUS SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS | DUPONT PHARMACEUTICALS COMPANY (US) | 1999-07-20 | — | — | US | disclosed |
| WO-1997038984-A1 | N-(AMIDINOPHENYL)-N'-(SUBST.)-3H-2,4-BENZODIAZEPIN-3-ONE DERIVATIVES AS FACTOR XA INHIBITORS | DU PONT PHARMACEUTICALS COMPANY (US) | 1997-10-23 | — | — | WO | disclosed |