Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 17/20 | 0.47 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6806885 | 0.83 | PARP1 (0.63) | PARP1DHODHCHEK2 | |
| SCHEMBL6585182 | 0.83 | PARP1 (0.47) | PARP1HPSEDHODHPLA2G2AALOX15 | |
| SCHEMBL6578530 | 0.79 | PARP1 (0.67) | PARP1HPSEDHODH | |
| SCHEMBL6589950 | 0.79 | PKN1 (0.46) | PARP1HPSEDHODHPLA2G2AALOX15 | |
| SCHEMBL6585526 | 0.78 | PARP1 (0.47) | PARP1HPSEDHODHCHEK2 | |
| SCHEMBL6384512 | 0.77 | PARP1 (0.56) | PARP1HPSEDHODHPLA2G2AALOX15 | |
| SCHEMBL6590709 | 0.77 | PKN1 (0.66) | PARP1HPSEDHODHPLA2G2AALOX15 | |
| SCHEMBL6383675 | 0.76 | PARP1 (0.57) | PARP1DHODH | |
| SCHEMBL6380066 | 0.75 | PARP1 (0.55) | PARP1 | |
| SCHEMBL6586775 | 0.75 | PARP1 (0.46) | PARP1HPSEDHODHPLA2G2AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1177178-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000068206-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2000-11-16 | — | — | WO | disclosed |