Sugi Predict

Sugi Predict / Compounds / Pyridine

Pyridine

Pyridine

SCHEMBL6586124

C#Cc1nnc(Cc2c(Cl)cncc2Cl)c2ccc(OC)cc12.c1ccncc1

nearest known ligand 0.88

Full drug profile on Sugi Atlas →

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ PDE4A P27815 19/20 0.88
▸ PDE4B Q07343 19/20 0.88
▸ PDE4C Q08493 19/20 0.88
▸ PDE4D Q08499 19/20 0.88
▸ KDR P35968 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6591087 0.94 PDE4A (1.00) PDE4APDE4BPDE4CPDE4D
SCHEMBL6587239 0.91 PDE4A (0.94) PDE4APDE4BPDE4CPDE4D
SCHEMBL6585377 0.90 PDE4A (0.88) PDE4APDE4BPDE4CPDE4DKDR
SCHEMBL6587228 0.83 PDE4A (1.00) PDE4APDE4BPDE4CPDE4D
SCHEMBL6583967 0.83 PDE4A (0.79) PDE4APDE4BPDE4CPDE4D
Pyridine SCHEMBL6587466 0.80 PDE4A (0.55) PDE4APDE4BPDE4CPDE4D
SCHEMBL6587900 0.79 PDE4A (0.72) PDE4APDE4BPDE4CPDE4D
SCHEMBL6589991 0.79 PDE4A (0.72) PDE4APDE4BPDE4CPDE4D
SCHEMBL6589078 0.79 PDE4A (0.72) PDE4APDE4BPDE4CPDE4D
SCHEMBL4701651 0.79 PDE4A (0.72) PDE4APDE4BPDE4CPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1097142-B1 PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS ZAMBON SPA (IT) 2004-10-13 — — EP disclosed
US-6492360-B1 Phthalazine derivatives phosphodiesterase 4 inhibitors ZAMBON GROUP S.P.A. (IT) 2002-12-10 — — US disclosed