Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 8/20 | 0.42 |
| ▸ | ST14 | Q9Y5Y6 | 8/20 | 0.42 |
| ▸ | HPN | P05981 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.39 |
| ▸ | F2 | P00734 | 5/20 | 0.39 |
| ▸ | PLG | P00747 | 5/20 | 0.39 |
| ▸ | PLAU | P00749 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.37 |
| ▸ | CCKBR | P32239 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7540321 | 0.91 | F10 (0.43) | F10ST14HPNPRSS1PRSS2 | |
| SCHEMBL6588093 | 0.86 | TP53 (0.51) | F10ST14HPNPRSS1PRSS2 | |
| SCHEMBL6615251 | 0.85 | ST14 (0.40) | F10ST14HPNPRSS1PRSS2 | |
| SCHEMBL6584604 | 0.84 | F10 (0.46) | F10ST14HPNPRSS1PRSS2 | |
| SCHEMBL7248310 | 0.84 | F10 (0.46) | F10ST14HPNPRSS1PRSS2 | |
| SCHEMBL6582723 | 0.84 | NPC1 (0.48) | SMN1; SMN2ALOX15 | |
| SCHEMBL6582385 | 0.84 | F10 (0.48) | F10ST14HPNPRSS1PRSS2 | |
| SCHEMBL6582583 | 0.84 | CNR1 (0.54) | F10ST14HPNPRSS1PRSS2 | |
| SCHEMBL6590427 | 0.84 | F10 (0.52) | F10ST14HPNPRSS1PRSS2 | |
| SCHEMBL6588145 | 0.83 | GAA (0.54) | F10PRSS1EPHX2F2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0960104-B1 | N-(AMIDINOPHENYL)-N'-(SUBST.)-3H-2,4-BENZODIAZEPIN-3-ONE DERIVATIVES AS FACTOR XA INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2004-06-16 | — | — | EP | claimed |
| US-6521614-B1 | Anticoagulant agents for treatment and prevention of thromboembolic disorders | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-02-18 | — | — | US | claimed |
| US-6521614-B1 | Anticoagulant agents for treatment and prevention of thromboembolic disorders | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-02-18 | — | — | US | disclosed |
| US-5925635-A | 2-(OXO-1,3-PERHYDRODIAZEPINES OR 3-OXO-2,3,4,5-TETRAHYDRO-1H-2,4-BENZODIAZEPINES; ANTICOAGULANTS; ENZYME INHIBITORS OF SERINE PROTEASE THROMBIN, KALLIKREIN AND PLASMIN; NERVOUS SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS | DUPONT PHARMACEUTICALS COMPANY (US) | 1999-07-20 | — | — | US | disclosed |