Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 17/20 | 0.74 |
| ▸ | PPARD | Q03181 | 8/20 | 0.61 |
| ▸ | PPARG | P37231 | 6/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6582740 | 0.92 | PPARA (0.82) | PPARAPPARDPPARGNPC1ALDH1A1 | |
| SCHEMBL6927188 | 0.92 | PPARA (0.73) | PPARAPPARDPPARG | |
| SCHEMBL6582462 | 0.85 | PPARA (1.00) | PPARAPPARDPPARGNPC1ALDH1A1 | |
| SCHEMBL5185069 | 0.83 | PPARA (0.82) | PPARAPPARDPPARG | |
| SCHEMBL27728329 | 0.81 | PPARA (0.73) | PPARAPPARDPPARGNPC1ALDH1A1 | |
| SCHEMBL3997800 | 0.77 | PPARA (0.67) | PPARAPPARDPPARGNPC1ALDH1A1 | |
| SCHEMBL6586288 | 0.76 | PPARA (0.59) | PPARAPPARDPPARGNPC1ALDH1A1 | |
| Gw590735 SCHEMBL3673228 | 0.76 | PPARA (1.00) | PPARAPPARDPPARG | |
| SCHEMBL6584609 | 0.76 | PPARA (0.70) | PPARAPPARDPPARGNPC1ALDH1A1 | |
| SCHEMBL6582734 | 0.76 | PPARA (0.60) | PPARAPPARDPPARGNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244642-B1 | SUBSTITUTED OXAZOLES AND THIAZOLES DERIVATIVES AS HPPAR ALPHA ACTIVATORS | GLAXO GROUP LTD (GB) | 2004-04-28 | — | — | EP | claimed |
| US-6518290-B1 | Compounds that activate or otherwise interact with one or more of the PPARs have been implicated in the regulation of triglyceride and cholesterol levels in animal models | SMITHKLINE BEECHAM CORPORATION | 2003-02-11 | — | — | US | claimed |
| EP-1244642-B1 | SUBSTITUTED OXAZOLES AND THIAZOLES DERIVATIVES AS HPPAR ALPHA ACTIVATORS | GLAXO GROUP LTD (GB) | 2004-04-28 | — | — | EP | disclosed |
| US-6518290-B1 | Compounds that activate or otherwise interact with one or more of the PPARs have been implicated in the regulation of triglyceride and cholesterol levels in animal models | SMITHKLINE BEECHAM CORPORATION | 2003-02-11 | — | — | US | disclosed |