Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27451484 | 0.88 | METAP1 (0.38) | METAP1BRD9CA1CA2PSMB8 | |
| SCHEMBL1066439 | 0.84 | METAP1 (0.45) | METAP1BRD9CA1CA2PSMB8 | |
| SCHEMBL27450991 | 0.81 | METAP1 (0.38) | METAP1BRD9CA1CA2PSMB8 | |
| SCHEMBL5029628 | 0.78 | PTPN1 (0.56) | METAP1BRD9CA1CA2PSMB8 | |
| SCHEMBL3039310 | 0.78 | MAPT (0.49) | METAP1BRD9CA1CA2PSMB8 | |
| SCHEMBL4636495 | 0.77 | BRD9 (0.45) | METAP1BRD9CA1MEN1NPC1 | |
| SCHEMBL23960291 | 0.76 | ATR (0.43) | METAP1BRD9CA1CA2PSMB8 | |
| SCHEMBL22774998 | 0.76 | CA1 (0.42) | METAP1BRD9CA1CA2PSMB8 | |
| SCHEMBL1483110 | 0.76 | CA1 (0.42) | METAP1BRD9CA1CA2PSMB8 | |
| SCHEMBL3633543 | 0.75 | PTGDR2 (0.40) | METAP1BRD9CA1CA2PSMB8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |