SCHEMBL6586882

SCHEMBL6586882

Cc1nc(Cl)cc(-c2ccccc2Cl)n1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 5/20 0.64
HSP90AB1 P08238 5/20 0.64
HSD11B1 P28845 1/20 0.43
IDO1 P14902 1/20 0.42
KMT2A Q03164 4/20 0.40
KDM5B Q9UGL1 1/20 0.40
MAOB P27338 1/20 0.40
NPY5R Q15761 1/20 0.40
GSK3B P49841 1/20 0.40
ALDH1A1 P00352 2/20 0.40
KDM4E B2RXH2 1/20 0.40
HPGD P15428 1/20 0.40
POLB P06746 1/20 0.40
PLA2G7 Q13093 1/20 0.40
ADORA2A P29274 1/20 0.39
ADORA1 P30542 1/20 0.39
MEN1 O00255 2/20 0.39
NPC1 O15118 1/20 0.39
LMNA P02545 1/20 0.39
RAB9A P51151 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL602372 0.85 HSP90AA1 (0.46) HSP90AA1HSP90AB1IDO1KMT2AMAOB
SCHEMBL6588868 0.82 HSP90AA1 (0.47) HSP90AA1HSP90AB1HSD11B1IDO1KMT2A
SCHEMBL25068017 0.82 KDM4E (0.46) HSP90AA1HSP90AB1KMT2AALDH1A1KDM4E
SCHEMBL602995 0.82 MAPK14 (0.45) HSP90AA1HSP90AB1HSD11B1ADORA2AADORA1
SCHEMBL12303170 0.81 HSP90AA1 (0.59) HSP90AA1HSP90AB1HSD11B1IDO1KMT2A
SCHEMBL3327517 0.81 HSP90AA1 (0.68) HSP90AA1HSP90AB1IDO1KMT2AKDM5B
SCHEMBL6589616 0.80 HSP90AA1 (0.65) HSP90AA1HSP90AB1HSD11B1KMT2AKDM4E
SCHEMBL602804 0.78 ADORA2A (0.47) HSP90AA1HSP90AB1HSD11B1KMT2AMAOB
SCHEMBL27865668 0.78 DPP4 (0.46) HSP90AA1HSP90AB1KMT2AKDM4EMEN1
SCHEMBL3950560 0.78 HSP90AA1 (1.00) HSP90AA1HSP90AB1KMT2AGSK3BKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0781766-B1 HETEROCYCLIC DERIVATIVE AND MEDICINE NIPPON SHINYAKU CO LTD (JP) 2004-03-31 EP disclosed
CN-1118454-C Heterocyclic derivative and medicine NIPPON SHINYAKU CO LTD (JP) 2003-08-20 CN disclosed
US-6191149-B1 DRUG FOR CEREBROVASCULAR DISEASE NIPPON SHINYAKU, CO., LTD. (JP) 2001-02-20 US disclosed
US-5945426-A PREVENT NEURONAL DEATH NIPPON SHINYAKU CO., LTD. (JP) 1999-08-31 US disclosed
CN-1157609-A Heterocyclic derivative and medicine NIPPON SHINYAKU CO LTD (JP) 1997-08-20 CN disclosed
EP-0781766-A1 HETEROCYCLIC DERIVATIVE AND MEDICINE NIPPON SHINYAKU COMPANY, LIMITED (JP) 1997-07-02 EP disclosed