Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 2/20 | 0.43 |
| ▸ | OGG1 | O15527 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | PDE9A | O76083 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6586914 | 1.00 | EPHX2 (0.44) | EPHX2CYP2C9CYP2J2ACACBOGG1 | |
| SCHEMBL6584945 | 0.88 | CHRNA7 (0.41) | EPHX2CYP2C9CYP2J2ACACBCHRNA7 | |
| SCHEMBL6584937 | 0.88 | CHRNA7 (0.41) | EPHX2CYP2C9CYP2J2ACACBCHRNA7 | |
| SCHEMBL6585234 | 0.86 | EPHX2 (0.47) | EPHX2CYP2C9CYP2J2ACACBCHRNA7 | |
| SCHEMBL6586275 | 0.86 | EPHX2 (0.47) | EPHX2CYP2C9CYP2J2ACACBCHRNA7 | |
| SCHEMBL6585239 | 0.86 | EPHX2 (0.47) | EPHX2CYP2C9CYP2J2ACACBCHRNA7 | |
| SCHEMBL6585993 | 0.85 | CCR3 (0.45) | EPHX2CHRNA7SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL6585997 | 0.85 | CCR3 (0.45) | EPHX2CHRNA7SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL6584876 | 0.84 | KDM4E (0.49) | EPHX2ACACBSCN9ASLC6A4SLC6A2 | |
| SCHEMBL9450842 | 0.83 | EPHX2 (0.50) | EPHX2CYP2C9CYP2J2OGG1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1049671-B1 | AZETIDINECARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS | VERNALIS RES LTD (GB) | 2004-04-21 | — | — | EP | claimed |
| US-6514961-B1 | Such as anxiety and all forms of epilepsy, particularly in humans | VERNALIS RESEARCH LIMITED (GB) | 2003-02-04 | — | — | US | claimed |