Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 17/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 17/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 17/20 | 0.52 |
| ▸ | CTSD | P07339 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584886 | 0.89 | PDE4B (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6585434 | 0.83 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6588260 | 0.81 | PDE4B (0.51) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6582399 | 0.81 | PDE4B (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6585249 | 0.79 | PDE4B (0.56) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6584639 | 0.77 | PDE4B (0.52) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6584436 | 0.77 | PDE4B (0.56) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7763150 | 0.73 | PDE4B (0.64) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7764127 | 0.73 | PDE4B (0.64) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7763127 | 0.73 | PDE4B (0.64) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0928789-B1 | 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | NIKKEN CHEMICALS CO LTD (JP) | 2004-09-29 | — | — | EP | disclosed |
| US-6251897-B1 | TREATING DERMATITIS, ASTHMA | NIKKEN CHEMICALS CO., LTD (JP) | 2001-06-26 | — | — | US | disclosed |
| EP-0928789-A1 | 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-07-14 | — | — | EP | disclosed |