Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.66 |
| ▸ | MAPK13 | O15264 | 10/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.51 |
| ▸ | GCGR | P47871 | 2/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1127766 | 1.00 | MAPK14 (0.66) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL6581107 | 0.86 | MAPK14 (0.66) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5858720 | 0.86 | MAPK14 (0.66) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL7139249 | 0.86 | MAPK14 (0.66) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL13670475 | 0.84 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5903491 | 0.82 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5998654 | 0.82 | MAPK14 (0.87) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL27489999 | 0.81 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL7162537 | 0.81 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5820266 | 0.81 | MAPK14 (0.85) | MAPK14MAPK13MAPK12MAPK11GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392678-A2 | PROCESS FOR THE PREPARATION OF TETRASUBSTITUTED IMIDAZOLE DERIVATIVES AND NOVEL CRYSTALLINE STRUCTURES THEREOF | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002076974-A2 | PROCESS FOR THE PREPARATION OF TETRASUBSTITUTED IMIDAZOLE DERIVATIVES AND NOVEL CRYSTALLINE STRUCTURES THEREOF | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2002-10-03 | — | — | WO | disclosed |