Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6586651 | 0.89 | RXFP1 (0.61) | RXFP1TSHRTP53SMN1; SMN2MEN1 | |
| Fumaric Acid SCHEMBL6589338 | 0.82 | RXFP1 (0.56) | RXFP1TSHRTP53SMN1; SMN2MEN1 | |
| Maleic Acid SCHEMBL6589328 | 0.82 | RXFP1 (0.56) | RXFP1TSHRTP53SMN1; SMN2MEN1 | |
| SCHEMBL6589296 | 0.79 | RXFP1 (0.66) | RXFP1TSHRTP53SMN1; SMN2MEN1 | |
| Fumaric Acid SCHEMBL6588746 | 0.72 | RXFP1 (0.60) | RXFP1TSHRTP53MEN1KMT2A | |
| Fumaric Acid SCHEMBL6588742 | 0.72 | RXFP1 (0.60) | RXFP1TSHRTP53MEN1KMT2A | |
| SCHEMBL6589332 | 0.71 | RXFP1 (0.49) | RXFP1TSHRTP53SMN1; SMN2PGR | |
| SCHEMBL29209617 | 0.71 | MEN1 (0.67) | RXFP1TSHRTP53SMN1; SMN2MEN1 | |
| SCHEMBL29031855 | 0.70 | CES1 (0.46) | TSHRMEN1MAPTKMT2APGR | |
| SCHEMBL6589132 | 0.69 | RXFP1 (0.53) | RXFP1TSHRTP53SMN1; SMN2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0703232-B1 | 2,3-Dihydro-1H-isoindole derivates, a process for their preparation and their use as serotonin reuptake inhibitors | AVENTIS PHARMA INC (US) | 2004-06-30 | — | — | EP | disclosed |
| US-5874458-A | PSYCHOLOGICAL DISORDERS | HOECHST MARION ROUSSEL INC. (US) | 1999-02-23 | — | — | US | disclosed |
| US-5874583-A | TREATING DEPRESSION, OBSESSIVE COMPULSIVE DISORDER, STUTTERING, TRICHOTILLOMANIA | HOECHST MARION ROUSSEL INC. (US) | 1999-02-23 | — | — | US | disclosed |
| US-5869685-A | SEROTONIN REUPTAKE INHIBITORS | HOECHST MARION ROUSSEL INC. (US) | 1999-02-09 | — | — | US | disclosed |
| US-5869502-A | TREATING DEPRESSION, OBSESSIVE COMPULSIVE DISORDER, STUTTERING, TRICHOTILLOMANIA | HOECHST MARION ROUSSEL INC. (US) | 1999-02-09 | — | — | US | disclosed |
| US-5567718-A | PSYCHOLOGICAL DISORDERS | HOECHST MARION ROUSSEL INC. (US) | 1996-10-22 | — | — | US | disclosed |
| EP-0703232-A2 | 2,3-Dihydro-1H-isoindole derivates, a process for their preparation and their use as serotonin reuptake inhibitors | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1996-03-27 | — | — | EP | disclosed |