Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 5/20 | 0.54 |
| ▸ | AURKA | O14965 | 3/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | PARP1 | P09874 | 12/20 | 0.47 |
| ▸ | PIM1 | P11309 | 2/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587823 | 0.95 | AURKB (0.55) | AURKBAURKAKDRPARP1PIM1 | |
| SCHEMBL6588008 | 0.93 | AURKB (0.53) | AURKBAURKAKDRPARP1PIM1 | |
| SCHEMBL6591260 | 0.91 | KDR (0.57) | AURKBAURKAKDRPARP1PIM1 | |
| SCHEMBL6591233 | 0.90 | AURKB (0.51) | AURKBAURKAKDRPARP1PIM1 | |
| SCHEMBL6588118 | 0.89 | AURKB (0.49) | AURKBAURKAKDRPARP1PIM1 | |
| SCHEMBL6810368 | 0.88 | AURKB (0.70) | AURKBAURKAKDRPARP1PIM1 | |
| SCHEMBL6588006 | 0.88 | AURKB (0.54) | AURKBAURKAKDRPARP1PIM1 | |
| SCHEMBL6586447 | 0.86 | AURKB (0.46) | AURKBAURKAKDRPARP1PIM1 | |
| SCHEMBL6806355 | 0.86 | AURKB (0.67) | AURKBAURKAKDRPARP1PIM1 | |
| SCHEMBL6585555 | 0.86 | AURKB (0.50) | AURKBAURKAKDRPARP1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |