Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 5/20 | 0.54 |
| ▸ | PIM1 | P11309 | 2/20 | 0.54 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 12/20 | 0.49 |
| ▸ | DHODH | Q02127 | 5/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585672 | 0.99 | AURKB (0.54) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL6583706 | 0.94 | AURKB (0.50) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL6584805 | 0.94 | AURKB (0.48) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL6587027 | 0.94 | AURKB (0.48) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL6585555 | 0.93 | AURKB (0.50) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL6587436 | 0.93 | AURKB (0.49) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL6588334 | 0.92 | AURKB (0.49) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL6588008 | 0.91 | AURKB (0.53) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL6587823 | 0.90 | AURKB (0.55) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL6586447 | 0.89 | AURKB (0.46) | AURKBPIM1PIM3MKNK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1177178-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2001082877-A2 | USE OF PARP INHIBITORS IN COSMETIC PREPARATIONS | BASF AKTIENGESELLSCHAFT (DE) | 2001-11-08 | — | — | WO | disclosed |
| WO-2000068206-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2000-11-16 | — | — | WO | disclosed |