Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | BRD2 | P25440 | 1/20 | 0.47 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | CETP | P11597 | 12/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587647 | 1.00 | BRD4 (0.47) | BRD4BRD2BRD3PTGDR2CETP | |
| SCHEMBL6588253 | 0.90 | CETP (0.55) | BRD4BRD2BRD3CETP | |
| SCHEMBL1903767 | 0.90 | CETP (0.55) | BRD4BRD2BRD3CETP | |
| SCHEMBL1899816 | 0.88 | CETP (0.49) | BRD4BRD2BRD3CETP | |
| SCHEMBL1899531 | 0.85 | CETP (0.59) | CETP | |
| SCHEMBL7820687 | 0.85 | CETP (0.59) | CETP | |
| SCHEMBL5413690 | 0.81 | PTGDR2 (0.60) | PTGDR2 | |
| SCHEMBL5402943 | 0.81 | PTGDR2 (0.60) | PTGDR2 | |
| SCHEMBL5413692 | 0.81 | PTGDR2 (0.60) | PTGDR2 | |
| SCHEMBL5402933 | 0.81 | PTGDR2 (0.60) | PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1114033-B1 | 4-CARBOXYAMINO-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINES AS CETP INHIBITORS | PFIZER PROD INC (US) | 2004-09-29 | — | — | EP | disclosed |
| US-6395751-B1 | SYNERGISTIC MIXTURE; ANTICHOLESTEROL AGENTS | PFIZER INC. | 2002-05-28 | — | — | US | disclosed |
| US-6147090-A | CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS USED TO TREAT DISEASES WHICH ARE EXACERBATED BY LOW LEVELS OF HDL CHOLESTEROL AND/OR HIGH LEVELS OF LDL-CHOLESTEROL AND TRIGLYCERIDES, SUCH AS ATHEROSCLEROSIS AND CARDIOVASCULAR | PFIZER INC. (US) | 2000-11-14 | — | — | US | disclosed |