Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.60 |
| ▸ | SRC | P12931 | 14/20 | 0.53 |
| ▸ | KDR | P35968 | 7/20 | 0.53 |
| ▸ | EGFR | P00533 | 4/20 | 0.51 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4508490 | 0.99 | CHEK1 (0.59) | CHEK1SRCKDREGFRKDM1A | |
| SCHEMBL7205355 | 0.94 | CHEK1 (0.54) | CHEK1SRCKDREGFRKDM1A | |
| Hydrochloric Acid SCHEMBL7211125 | 0.93 | CHEK1 (0.54) | CHEK1SRCKDREGFRKDM1A | |
| SCHEMBL4506578 | 0.91 | CHEK1 (0.60) | CHEK1SRCKDREGFRKDM1A | |
| Hydrochloric Acid SCHEMBL7205696 | 0.90 | CHEK1 (0.59) | CHEK1SRCKDREGFRKDM1A | |
| SCHEMBL7205019 | 0.90 | CHEK1 (0.58) | CHEK1SRCKDREGFRKDM1A | |
| SCHEMBL7211414 | 0.90 | CHEK1 (0.58) | CHEK1SRCKDREGFRKDM1A | |
| Hydrochloric Acid SCHEMBL7211395 | 0.89 | CHEK1 (0.57) | CHEK1SRCKDREGFRKDM1A | |
| SCHEMBL7209528 | 0.89 | CHEK1 (0.58) | CHEK1SRCKDREGFRKDM1A | |
| SCHEMBL4519142 | 0.89 | CHEK1 (0.77) | CHEK1SRCKDREGFRKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458394-A1 | USE OF OXINDOLE DERIVATIVES IN THE TREATMENT OF DEMENTIA RELATED DISEASES, ALZHEIMER S DISEASE AND CONDITIONS ASSOCIATED WITH GLYCOGEN SYNTHASE KINASE-3 | AstraZeneca AB (SE) | 2004-09-22 | — | — | EP | claimed |
| WO-2003055492-A1 | USE OF OXINDOLE DERIVATIVES IN THE TREATMENT OF DEMENTIA RELATED DISEASES, ALZHEIMER'S DISEASE AND CONDITIONS ASSOCIATED WITH GLYCOGEN SYNTHASE KINASE-3 | ASTRAZENECA AB (SE) | 2003-07-10 | — | — | WO | claimed |
| EP-1458394-A1 | USE OF OXINDOLE DERIVATIVES IN THE TREATMENT OF DEMENTIA RELATED DISEASES, ALZHEIMER S DISEASE AND CONDITIONS ASSOCIATED WITH GLYCOGEN SYNTHASE KINASE-3 | AstraZeneca AB (SE) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003055492-A1 | USE OF OXINDOLE DERIVATIVES IN THE TREATMENT OF DEMENTIA RELATED DISEASES, ALZHEIMER'S DISEASE AND CONDITIONS ASSOCIATED WITH GLYCOGEN SYNTHASE KINASE-3 | ASTRAZENECA AB (SE) | 2003-07-10 | — | — | WO | disclosed |