SCHEMBL6589518

SCHEMBL6589518

CN(Cc1csc(C(=O)Nc2c(C(=O)Nc3ccc(Cl)cc3)cc(Cl)cc2N2CCOCC2)c1Cl)C1=NCCO1

nearest known ligand 0.64

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
F2 P00734 17/20 0.64
KLKB1 P03952 1/20 0.64
F10 P00742 18/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6591077 0.92 F2 (0.78) F2KLKB1F10
SCHEMBL6589474 0.87 F2 (0.84) F2KLKB1F10
SCHEMBL6592238 0.85 F10 (0.66) F2F10
SCHEMBL6590878 0.84 F10 (0.59) F2KLKB1F10
SCHEMBL6591771 0.84 F10 (0.60) F2F10
SCHEMBL6591547 0.83 F2 (0.78) F2KLKB1F10
SCHEMBL6592631 0.79 F2 (0.84) F2KLKB1F10
SCHEMBL6589910 0.78 F2 (0.72) F2KLKB1F10
SCHEMBL6590538 0.78 F2 (0.61) F2KLKB1F10
SCHEMBL6587511 0.78 F2 (0.73) F2KLKB1F10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1143855-C I (ortho)-anthranilamide derivatives as anti-coagulants ���ֹɷݹ�˾ 2004-03-31 CN claimed
EP-1040108-B1 ORTHO-ANTHRANILAMIDE DERIVATIVES AS ANTI-COAGULANTS SCHERING AG (DE) 2004-02-25 EP claimed
US-6498185-B1 ENZYME FACTOR XA INHIBITORS BERLEX LABORATORIES, INC. 2002-12-24 US claimed
CN-1143855-C I (ortho)-anthranilamide derivatives as anti-coagulants ���ֹɷݹ�˾ 2004-03-31 CN disclosed
EP-1040108-B1 ORTHO-ANTHRANILAMIDE DERIVATIVES AS ANTI-COAGULANTS SCHERING AG (DE) 2004-02-25 EP disclosed
US-6498185-B1 ENZYME FACTOR XA INHIBITORS BERLEX LABORATORIES, INC. 2002-12-24 US disclosed
US-6380221-B1 FOR THERAPY OF DISEASE-STATES CHARACTERIZED BY THROMBOTIC ACTIVITY BERLEX LABORATORIES, INC. 2002-04-30 US disclosed
CN-1282329-A I (ortho)-anthranilamide derivatives as anti-coagulants SCHERING AG (DE) 2001-01-31 CN disclosed
US-6140351-A FOR TREATING THROMBOSIS BERLEX LABORATORIES, INC. (US) 2000-10-31 US disclosed