Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 17/20 | 0.67 |
| ▸ | PDE4B | Q07343 | 17/20 | 0.67 |
| ▸ | PDE4C | Q08493 | 17/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 17/20 | 0.67 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.37 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587944 | 0.85 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL6585212 | 0.80 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL6592467 | 0.79 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6587228 | 0.78 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6583967 | 0.77 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6591087 | 0.77 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6587981 | 0.76 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6588133 | 0.76 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6587239 | 0.75 | PDE4A (0.94) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6589078 | 0.74 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097142-B1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON SPA (IT) | 2004-10-13 | — | — | EP | disclosed |
| US-6329370-B1 | CARDIOVASCULAR DISORDERS AND TUMOR NECROSIS FACTOR (HEREINAFTER TNF.SUB..ALPHA.), A CYTOKINE WITH PRO-INFLAMMATORY ACTIVITY | ZAMBON GROUP S.P.A. (IT) | 2001-12-11 | — | — | US | disclosed |