SCHEMBL6589645

SCHEMBL6589645

CCN(Cc1csc(C(=O)Nc2c(OC)cc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)c1Cl)C1=NCCO1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
F2 P00734 18/20 1.00
F10 P00742 16/20 1.00
KLKB1 P03952 2/20 0.84
ELANE P08246 1/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6590572 0.93 F2 (1.00) F2F10KLKB1ELANE
SCHEMBL6590681 0.92 F10 (1.00) F2F10KLKB1ELANE
SCHEMBL6591486 0.91 F2 (1.00) F2F10KLKB1ELANE
SCHEMBL6591547 0.88 F2 (0.78) F2F10KLKB1
SCHEMBL6594632 0.86 F2 (0.84) F2F10KLKB1
SCHEMBL6590267 0.86 F2 (1.00) F2F10KLKB1ELANE
SCHEMBL6594294 0.85 F2 (0.84) F2F10KLKB1ELANE
SCHEMBL6589922 0.85 F2 (1.00) F2F10KLKB1ELANE
SCHEMBL6590183 0.84 F2 (0.86) F2F10KLKB1ELANE
SCHEMBL6592375 0.83 F2 (0.75) F2F10KLKB1ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1040108-B1 ORTHO-ANTHRANILAMIDE DERIVATIVES AS ANTI-COAGULANTS SCHERING AG (DE) 2004-02-25 EP claimed
EP-1040108-B1 ORTHO-ANTHRANILAMIDE DERIVATIVES AS ANTI-COAGULANTS SCHERING AG (DE) 2004-02-25 EP disclosed
US-6498185-B1 ENZYME FACTOR XA INHIBITORS BERLEX LABORATORIES, INC. 2002-12-24 US disclosed
US-6380221-B1 FOR THERAPY OF DISEASE-STATES CHARACTERIZED BY THROMBOTIC ACTIVITY BERLEX LABORATORIES, INC. 2002-04-30 US disclosed
US-6140351-A FOR TREATING THROMBOSIS BERLEX LABORATORIES, INC. (US) 2000-10-31 US disclosed