Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | BUB1 | O43683 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | STS | P08842 | 2/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12414130 | 0.80 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1BCHEBUB1PIK3R1 | |
| SCHEMBL3835540 | 0.78 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1BCHEBUB1PIK3R1 | |
| SCHEMBL24440780 | 0.76 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1BCHEBUB1PIK3R1 | |
| SCHEMBL8079706 | 0.72 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1BCHEBUB1PIK3R1 | |
| SCHEMBL5849613 | 0.72 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1BCHEBUB1PIK3R1 | |
| SCHEMBL163016 | 0.72 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1BCHEBUB1PIK3R1 | |
| SCHEMBL15417736 | 0.72 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1BCHEBUB1PIK3R1 | |
| SCHEMBL4916320 | 0.72 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1BCHEBUB1PIK3R1 | |
| SCHEMBL367386 | 0.71 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1BCHEBUB1PIK3R1 | |
| SCHEMBL6591961 | 0.70 | BCHE (0.35) | BCHEBUB1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1231479-C | Naphthostyrils compounds | HOFFMANN LA ROCHE (CH) | 2005-12-14 | — | — | CN | disclosed |
| EP-1358180-B1 | NAPHTHOSTYRIL DERIVATIVES AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASES | HOFFMANN LA ROCHE (CH) | 2004-12-01 | — | — | EP | disclosed |
| CN-1487931-A | Naphthostyrils compounds | - | 2004-04-07 | — | — | CN | disclosed |
| US-6531598-B1 | Naphthostyrils | HOFFMANN-LA ROCHE INC. | 2003-03-11 | — | — | US | disclosed |
| US-6504034-B2 | Cell antiproliferative agents; anticancer agents | HOFFMANN-LA ROCHE INC. | 2003-01-07 | — | — | US | disclosed |
| US-20020147343-A1 | Naphthostyrils | CHEN YI (US) | 2002-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020147343-A1 | Naphthostyrils | CCNI, CDKL1, CDK2 | HSP90AA1 2543/4885HSP90AB1 2505/4885BCHE 3532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.