Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.67 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.67 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.67 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6588375 | 0.99 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DEGFR | |
| SCHEMBL6592467 | 0.90 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6586660 | 0.80 | PDE4D (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6587924 | 0.79 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6588016 | 0.76 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6585375 | 0.74 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6586115 | 0.74 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6587081 | 0.72 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL6588857 | 0.71 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6585373 | 0.69 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097142-B1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON SPA (IT) | 2004-10-13 | — | — | EP | claimed |