Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 4/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | AR | P10275 | 2/20 | 0.49 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.45 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4833670 | 0.88 | PARP1 (0.66) | PARP1CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL6586097 | 0.85 | ENPP1 (0.63) | PARP1CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL4702788 | 0.81 | CYP3A4 (0.53) | PARP1CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL4117496 | 0.81 | GAA (0.51) | CYP3A4CYP2C9TSHRCYP2C19AR | |
| SCHEMBL6608381 | 0.80 | PARP1 (0.54) | PARP1CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL5555992 | 0.80 | PARP1 (0.54) | PARP1CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL4131883 | 0.80 | GAA (0.50) | PARP1CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL6590866 | 0.79 | TSHR (0.48) | PARP1CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL6486531 | 0.79 | PDE4A (0.57) | CYP3A4CYP2C9TSHRCYP2C19AR | |
| SCHEMBL4837939 | 0.79 | MAPT (0.47) | CYP3A4CYP2C9TSHRCYP2C19AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097142-B1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON SPA (IT) | 2004-10-13 | — | — | EP | disclosed |
| EP-1371648-A1 | Phthalazine derivatives phosphodiesterase 4 inhibitors | ZAMBON GROUP S.p.A. (IT) | 2003-12-17 | — | — | EP | disclosed |
| US-6492360-B1 | Phthalazine derivatives phosphodiesterase 4 inhibitors | ZAMBON GROUP S.P.A. (IT) | 2002-12-10 | — | — | US | disclosed |
| US-6329370-B1 | CARDIOVASCULAR DISORDERS AND TUMOR NECROSIS FACTOR (HEREINAFTER TNF.SUB..ALPHA.), A CYTOKINE WITH PRO-INFLAMMATORY ACTIVITY | ZAMBON GROUP S.P.A. (IT) | 2001-12-11 | — | — | US | disclosed |
| EP-1097142-A1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.p.A. (IT) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000005218-A1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.P.A. (IT) | 2000-02-03 | — | — | WO | disclosed |