Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 3/20 | 0.64 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | P4HB | P07237 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | IL6 | P05231 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.37 |
| ▸ | MAX | P61244 | 1/20 | 0.37 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6590161 | 1.00 | TNF (0.64) | TNFNOD1RAB9ANFKB1MAOB | |
| SCHEMBL6591636 | 0.78 | TNF (1.00) | TNFNOD1RAB9ANFKB1MAOB | |
| SCHEMBL6597657 | 0.78 | TNF (0.76) | TNFNOD1RAB9ANFKB1MAOB | |
| SCHEMBL6591632 | 0.78 | TNF (1.00) | TNFNOD1RAB9ANFKB1MAOB | |
| SCHEMBL6597650 | 0.78 | TNF (0.76) | TNFNOD1RAB9ANFKB1MAOB | |
| SCHEMBL11024852 | 0.76 | TNF (0.51) | TNFNOD1RAB9ANFKB1MAOB | |
| SCHEMBL10149616 | 0.76 | TNF (0.51) | TNFNOD1RAB9ANFKB1MAOB | |
| SCHEMBL6591446 | 0.75 | TNF (0.83) | TNFNOD1RAB9ANFKB1MAOB | |
| SCHEMBL6592328 | 0.75 | TNF (0.71) | TNFNOD1RAB9ANFKB1MAOB | |
| SCHEMBL6591447 | 0.75 | TNF (0.83) | TNFNOD1RAB9ANFKB1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004016271-A1 | PYRIMIDONES AS ANTIVIRAL AGENTS | AXXIMA PHARMACEUTICALS AG (DE) | 2004-02-26 | — | — | WO | claimed |
| EP-1389461-A1 | Pyrimidones with antiviral properties | Axxima Pharmaceuticals Aktiengesellschaft (DE) | 2004-02-18 | — | — | EP | claimed |
| EP-1389461-A1 | Pyrimidones with antiviral properties | Axxima Pharmaceuticals Aktiengesellschaft (DE) | 2004-02-18 | — | — | EP | disclosed |