SCHEMBL6590341

SCHEMBL6590341

CN1CCC(N(C)Cc2csc(C(=O)Nc3c(C(=O)Nc4ccc(Cl)cn4)cc(Cl)cc3N3CCOCC3)c2Cl)CC1

nearest known ligand 0.59

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
F2 P00734 19/20 0.59
F10 P00742 17/20 0.59
KLKB1 P03952 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6589701 0.89 F2 (0.64) F2F10
SCHEMBL6590170 0.88 F2 (0.63) F2F10
SCHEMBL6588387 0.88 F10 (0.73) F2F10KLKB1
SCHEMBL6588942 0.88 F2 (0.64) F2F10KLKB1
SCHEMBL6590592 0.88 F2 (0.67) F2F10KLKB1
SCHEMBL6587511 0.88 F2 (0.73) F2F10KLKB1
SCHEMBL27472585 0.87 F2 (0.61) F2F10KLKB1
SCHEMBL6589910 0.87 F2 (0.72) F2F10KLKB1
SCHEMBL6593066 0.86 F2 (0.78) F2F10KLKB1
SCHEMBL6592537 0.86 F2 (0.73) F2F10KLKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1143855-C I (ortho)-anthranilamide derivatives as anti-coagulants ���ֹɷݹ�˾ 2004-03-31 CN claimed
EP-1040108-B1 ORTHO-ANTHRANILAMIDE DERIVATIVES AS ANTI-COAGULANTS SCHERING AG (DE) 2004-02-25 EP claimed
CN-1143855-C I (ortho)-anthranilamide derivatives as anti-coagulants ���ֹɷݹ�˾ 2004-03-31 CN disclosed
EP-1040108-B1 ORTHO-ANTHRANILAMIDE DERIVATIVES AS ANTI-COAGULANTS SCHERING AG (DE) 2004-02-25 EP disclosed
US-6498185-B1 ENZYME FACTOR XA INHIBITORS BERLEX LABORATORIES, INC. 2002-12-24 US disclosed
US-6380221-B1 FOR THERAPY OF DISEASE-STATES CHARACTERIZED BY THROMBOTIC ACTIVITY BERLEX LABORATORIES, INC. 2002-04-30 US disclosed
CN-1282329-A I (ortho)-anthranilamide derivatives as anti-coagulants SCHERING AG (DE) 2001-01-31 CN disclosed
US-6140351-A FOR TREATING THROMBOSIS BERLEX LABORATORIES, INC. (US) 2000-10-31 US disclosed