Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587983 | 0.85 | KDM4E (0.53) | KDM4EABCB1ALDH1A1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL6007678 | 0.84 | KDM4E (0.53) | KDM4EABCB1ALDH1A1KMT2AMEN1 | |
| Oxalic Acid SCHEMBL6595339 | 0.81 | MAPT (0.58) | KDM4EABCB1ALDH1A1KMT2AMEN1 | |
| SCHEMBL6588710 | 0.80 | MAPT (0.61) | KDM4EABCB1ALDH1A1KMT2AMEN1 | |
| SCHEMBL6589376 | 0.80 | MAPT (0.61) | KDM4EABCB1ALDH1A1KMT2AMEN1 | |
| Oxalic Acid SCHEMBL6589408 | 0.80 | CYP1A2 (0.68) | KDM4EABCB1ALDH1A1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL6591085 | 0.79 | CYP1A2 (0.60) | KDM4EABCB1ALDH1A1KMT2AMEN1 | |
| Fumaric Acid SCHEMBL6588817 | 0.78 | MAPT (0.56) | KDM4EABCB1ALDH1A1KMT2AMEN1 | |
| Fumaric Acid SCHEMBL6588822 | 0.78 | MAPT (0.56) | KDM4EABCB1ALDH1A1KMT2AMEN1 | |
| Cadaverine Tartrate SCHEMBL6589585 | 0.77 | MAPT (0.55) | KDM4EABCB1ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1186601-B1 | NOVEL ISOQUINOLINE DERIVATIVES OR SALTS THEREOF | YAMANOUCHI PHARMA CO LTD (JP) | 2004-03-24 | — | — | EP | disclosed |
| US-6573279-B1 | Drug, particularly to a novel isoquinoline derivative or its salt having an If current inhibitory effect without serious side effects such as convulsion and also to a drug, particularly a cardiac rate lowering agent, containing the | ASTELLAS PHARMA INC. (JP) | 2003-06-03 | — | — | US | disclosed |
| EP-1186601-A1 | NOVEL ISOQUINOLINE DERIVATIVES OR SALTS THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2002-03-13 | — | — | EP | disclosed |